Gene information
Official symbol CCL2
Official full name C-C motif chemokine ligand 2
Gene type protein-coding gene
Chromosome17q12
Alias symbolMCP1; MCP-1; MCAF; SMC-CF; GDCF-2; HC11; MGC9434
Previous symbolSCYA2
Gene familyChemokine ligands
Resources
Entrez Gene 6347
HGNC HGNC:10618
Ensembl ENSG00000108691
Vega OTTHUMG00000132887
UCSC uc002hhy.4
GO terms: 157 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002686 negative regulation of leukocyte migration GO Biological Processes -7.70467721 14 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002689 negative regulation of leukocyte chemotaxis GO Biological Processes -4.98522137 5 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007259 receptor signaling pathway via JAK-STAT GO Biological Processes -5.73581155 7 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008347 glial cell migration GO Biological Processes -5.57331468 10 More
GO:0008360 regulation of cell shape GO Biological Processes -5.20319448 20 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031663 lipopolysaccharide-mediated signaling pathway GO Biological Processes -14.0408172 12 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032411 positive regulation of transporter activity GO Biological Processes -5.68668981 10 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032414 positive regulation of ion transmembrane transporter activity GO Biological Processes -4.25838891 8 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043491 protein kinase B signaling GO Biological Processes -12.2973970 11 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044344 cellular response to fibroblast growth factor stimulus GO Biological Processes -7.12681878 10 More
GO:0045123 cellular extravasation GO Biological Processes -12.7826256 12 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048245 eosinophil chemotaxis GO Biological Processes -7.27705643 6 More
GO:0048246 macrophage chemotaxis GO Biological Processes -8.11586193 6 More
GO:0048247 lymphocyte chemotaxis GO Biological Processes -6.64704408 8 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050806 positive regulation of synaptic transmission GO Biological Processes -4.32260958 18 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050922 negative regulation of chemotaxis GO Biological Processes -8.57011989 17 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO Biological Processes -8.50460337 7 More
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO Biological Processes -7.53000143 6 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0051966 regulation of synaptic transmission, glutamatergic GO Biological Processes -5.51577792 8 More
GO:0051968 positive regulation of synaptic transmission, glutamatergic GO Biological Processes -3.21772170 4 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071346 cellular response to interferon-gamma GO Biological Processes -8.94844866 13 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071676 negative regulation of mononuclear cell migration GO Biological Processes -2.55598907 3 More
GO:0071774 response to fibroblast growth factor GO Biological Processes -7.87961599 11 More
GO:0072676 lymphocyte migration GO Biological Processes -7.69367801 10 More
GO:0072677 eosinophil migration GO Biological Processes -7.10577702 6 More
GO:0072678 T cell migration GO Biological Processes -4.46557398 5 More
GO:0090279 regulation of calcium ion import GO Biological Processes -9.31154255 13 More
GO:0090280 positive regulation of calcium ion import GO Biological Processes -7.46129980 6 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0097696 receptor signaling pathway via STAT GO Biological Processes -5.66899995 7 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0099601 regulation of neurotransmitter receptor activity GO Biological Processes -3.10443788 5 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1901623 regulation of lymphocyte chemotaxis GO Biological Processes -4.70812216 5 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1904783 positive regulation of NMDA glutamate receptor activity GO Biological Processes -6.54368931 4 More
GO:1905517 macrophage migration GO Biological Processes -7.27705643 6 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
GO:2000310 regulation of NMDA receptor activity GO Biological Processes -3.92081595 4 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2000401 regulation of lymphocyte migration GO Biological Processes -4.96687132 7 More
GO:2000402 negative regulation of lymphocyte migration GO Biological Processes -3.16989067 3 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
GO:2001259 positive regulation of cation channel activity GO Biological Processes -4.43623555 7 More
KEGG pathways: 17 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
bindarit TTD view
carlumab inhibitor ChemblInteractionsTTD view
risperidone PharmGKB 24495780 view
Related studies: 15 records
Molecular factor Omics type Application Objective MI type Reference
NM_002986.3:c.-2578G>A genomics myocardial infarction[diagnosis] myocardial infarction McDermott DH et al. Circulation. 2005
C-C motif chemokine 2 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Matsumori A et al. J Mol Cell Cardiol. 1997
C-C motif chemokine 2 proteomics enalapril[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Soejima H et al. J Am Coll Cardiol. 1999
C-C motif chemokine 2 proteomics heart failure[prognosis (bad)] acute myocardial infarction Parissis JT et al. J Interferon Cytokine Res. 2002
C-C motif chemokine 2 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Matsumoto N et al. Clin Appl Thromb Hemost. 2002
C-C motif chemokine 2 proteomics collateral circulation[prognosis (good)] acute myocardial infarction Park HJ et al. Int J Cardiol. 2008
C-C motif chemokine 2 proteomics edaravone[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Nakamura Y et al. J Cardiol. 2009
C-C motif chemokine 2 proteomics coronary restenosis[prognosis (bad)] acute ST elevation myocardial infarction Korybalska K et al. Clin Res Cardiol. 2010
C-C motif chemokine 2 proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Weir RA et al. Cytokine. 2010
C-C motif chemokine 2 proteomics glucose intolerance[prognosis (bad)] acute ST elevation myocardial infarction Knudsen EC et al. Cardiovasc Diabetol. 2010
C-C motif chemokine 2 proteomics medium predictor death[prognosis (bad)] acute ST elevation myocardial infarction Buyukkaya E et al. Am J Cardiol. 2013
C-C motif chemokine 2 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Buyukkaya E et al. Am J Cardiol. 2013
C-C motif chemokine 2 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Liu N et al. Exp Ther Med. 2019
NM_002986.3:c.-2578G>A genomics myocardial infarction[diagnosis] myocardial infarction Jemaa R et al. Clin Chim Acta. 2008
NM_002986.3:c.-2578G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction El Mahgoub IR et al. Blood Coagul Fibrinolysis. 2011
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